УВЭЖХ система Method Scouting предназначена для разработки методик. Программное обеспечение Method Scouting Solution и надежная система переключения колонок для автоматического подбора колонок и подвижных фаз обеспечивают быстрый и точный подбор оптимальных условий анализа при разработке методики.

• Selectable System Line-Up
  Method Scouting System is compatible with Shimadzu’s diverse LC product line-up and allows you to select the LC system that matches your objective, whether it be ultra fast analysis, SFC analysis, or simple method assessment.
• Fully Automated Method Scouting
  Method Scouting System is able to perform highly efficient and robust method scouting by automating entirely the switching between different combinations of mobile phases and columns.
• Simple Method Setting
  Method Scouting Solution dedicated method scouting software can reduce substantially the tedious work of method and batch generation.

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Selectable System Line-Up
Method scouting can now be performed with Shimadzu’s diverse LC product line-up. Choose the system suited to your laboratory environment, whether for SFC investigations or simple investigations on compact systems.

Nexera Method Scouting

Capable of automated investigation of conditions in the 130 MPa range, including 192 patterns of 8 mobile phases and 12 columns
Also capable of investigating pH conditions with mobile phase blending

Supercritical Fluid Chromatograph Nexera/UCs
UHPLC/SFC Switching System

Optimized for method investigation of chiral compounds
Also compatible with LC/SFC switching, for even greater efficiency improvements in method development

i-Series Method Scouting

Optimized for simple method development with a single pump
Space-saving, low-cost design

Fully Automated Method Scouting
Combine Method Scouting System with Method Scouting Solution dedicated software to achieve substantial efficiency improvements across all operations from method creation to data acquisition and analysis.

Leaving Method and Analysis Schedule Creation to Method Scouting Solution
Previous method scouting requires preparation of a method every time the column or mobile phase is changed. Investigating 100 different conditions requires the creation of 100 different method files, which is a substantial use of labor hours. Method Scouting Solution automatically creates methods with different columns, mobile phases, and gradient conditions from a single base method, allowing more effective use of your time.

Seamless Evaluation of Results in a Multi-Data Report
Data obtained by method scouting can be evaluated quantitatively with a multi-data report. By employing the evaluation method proposed by Shimadzu that uses resolution and peak detection number, chromatograms can be examined quantitatively and so help the user obtain an optimum method. When templates provided by Shimadzu are registered to Method Scouting Solution, reports are created and output simultaneous with completion of analysis, which allows rapid verification for optimum conditions.

Simple Method Setting
Method scouting can involve tedious work during method and batch generation, which is prone to resulting in operational errors.
The Method Scouting Solution graphical user interface is tailored to the system configuration and allows for intuitive and easy creation of method and batch schedules.

Improved Operating Rates Due to Automation of Analysis Sequences
Purge conditions and equilibration during automatic switching of mobile phases and columns are key issues in method scouting.
With Method Scouting Solution, these and all laboratory operations can be performed automatically based on conditions set in advance, from automated control to system checks and system shutdown.

Method Scouting Application

Improving Efficiency in the Preparation of Test Reports for Chemistry, Manufacturing, and Control (CMC) Using Multi Data Report
In order to demonstrate the quality of pharmaceutical products, pharmaceutical manufacturers must perform process studies into the active pharmaceutical ingredients (API) and studies into the pharmaceutical preparation process, and quality assessment for both of these as part of their chemistry, manufacturing, and control (CMC) activities. HPLC is used widely in such investigations for reaction tracing and impurity identification in API process studies, uniformity testing, and dissolution testing in pharmaceutical preparation development studies, and for analytical method validation in assay development for quality assessment studies. The results of these studies must be tabulated according to the objectives and summarized in reports. It is often the case that these results are copied into Excel or similar software before a report is created.

Ultra Fast Method Scouting (2) — Maximizing the Efficiency of Method Development
Due to the large amounts of time required for determining analytical conditions (method scouting), users are looking for ways to minimize the time required for method scouting. This report describes an example of using a Nexera Method Scouting system in combination with dedicated method scouting software to determine analytical conditions for simultaneous analysis of nine types of sulfa drugs. The dedicated method scouting software, Method Scouting Solution, is able to use the multi-data report functionality in LabSolutions DB/CS software to rapidly and optimal analytical conditions from huge amounts of analytical results. Therefore, this report also describes the multi-data report function.

Rapid Method Scouting of Chiral Compounds
Enantiomer resolution by chiral column chromatography is a variation of column chromatography that is actively being researched in the pharmaceutical field of drug discovery. One drawback of this method, however, is the extensive time and effort required to determine the optimum mobile phase conditions and the most suitable column for separation of the analyte among a wide variety of available chiral columns. This has spurred the demand for faster scouting of chiral separation conditions. Here, using the Nexera Method Scouting system with the iChiral-6 polysaccharide-based columns (Daicel Corporation), we report an example in which high-resolution column conditions are constructed for analysis of chiral compounds.