GCMS-TQ8050 NX

Трехквадрупольный газовый хроматомасс-спектрометр GCMS-TQ8050 NX

Описание
Sensitivity
Hardware
Performance
Operation
Products
Function

Описание

Квадрупольные газовые хроматомасс-спектрометры серии NX созданы на базе газового хроматографа Nexis GC-2030 и квадрупольных масс-селективных детекторов, которые используются в моделях GCMS-QP2020, GCMS-TQ8040 и GCMS-TQ8050. Как и все последние модели, серия NX относится к серии сверхбыстрых масс-спектрометров (UFMS). Сочетание новейшего газового хроматографа Nexis GC-2030 и апробированной модели масс-детектора даёт производительную и удобную в эксплуатации ГХМС систему — трехквадрупольный газовый хроматомасс-спектрометр GCMS-TQ8050 NX.

Enhanced Sensitivity
To maximize the benefits of the Off-Axis Ion Optics, the system features three noise-reduction technologies and a detector with improved amplification performance. Due to these state-of-the-art technologies, the system can reliably detect ultra-trace femtogram-level quantities of ions. The resulting exceptional analytical sensitivity and robustness increase the value of solutions and open the door to new applications.
Durable Hardware
In addition to ultra-high sensitivity, the GCMS-TQ8050 NX also offers high robustness. The contamination-resistant ion source and the new detector with over five times longer service life ensure that analysis can be performed reliably for a long time. With the ultra-high-sensitivity performance of the GCMS-TQ8050 NX, injection volumes can be reduced even further than before. The service life of inserts, columns, and other consumables can also be extended to reduce maintenance frequency and costs.
Superior Performance
A new turbomolecular pump with higher evacuation performance achieves a superior vacuum state in the MS unit, which also provides high sensitivity in the single GC-MS mode. With the high-efficiency collision cell (UFsweeper) installed as before, high-sensitivity detection is possible even when mass resolution is increased. The new active-time management function achieves further operating efficiencies by appropriately managing the wait times that occur during maintenance, while switching systems, or when the system is used by multiple users, to extend the operating time.
Reliable Operation
The Smart Database™ series, which are specialized for various fields, and Smart MRM™ function, which optimizes sensitivity, can be used to accurately create methods for ultra-trace analysis and reliably achieve high-sensitivity analysis from MRM measurements. LabSolutions Insight™ software, designed to support quantitative analysis of multianalyte data, enhances the throughput of data analysis from simultaneous analysis of multiple components in trace concentrations. The extensive accuracy control functions enable decisions to be made based on the easy-to-understand visualization of quantitative analysis and accuracy control results.

► Газовый тандемный хроматомасс-спектрометр GCMS-TQ8050 NX

► Газовые хроматомасс-спектрометры серии NX, листовка

Sensitivity

Enhanced Sensitivity

System That Detects Ultra-Trace Concentrations Not Previously Possible
To maximize the benefits of the Off-Axis Ion Optics, the system features three noise-reduction technologies and a detector with improved amplification performance. Due to these state-of-the-art technologies, the system can reliably detect ultra-trace femtogram-level quantities of ions. The resulting exceptional analytical sensitivity and robustness increase the value of solutions and open the door to new applications.

High-Efficiency Detector
The GCMS-TQ8050 NX detects peaks more reliably than the GCMS-TQ8040 NX, even for substances with fewer ions reaching the detector. That means it can reliably analyze femtogram-level concentrations with fewer ions.

OFF-AXIS Ion Optics

The OFF-AXIS Ion Optics eliminate noises such as metastable He ions without compromising sensitivity.

Shielded Detector

Noise from outside the detector was reduced by installing a shield in the secondary electron multiplier.

Overdrive Lens

Installing two lenses (overdrive lenses) in front of the electron multiplier reduces random noise from helium or argon and improves S/N. Applying voltage to the lenses improves S/N levels by reducing noise near the lenses and helping to focus the ions that pass through the mass filter (Patent No. US6737644).

The newly designed high-sensitivity detector offers excellent reliability even for samples with femtogram-level concentrations of trace components, achieving sub-femtogram IDL* levels.

*IDL: Instrument Detection Limit

The superior data stability with the GCMS-TQ8050 NX provides sensitivity that rivals high-resolution GC-MS analysis. This powerful new analytical instrument reliably identifies peaks even for trace quantities of dioxins and other substances previously considered difficult to analyze using a quadrupole GC-MS system.

Due to their tendency to resist degradation and remain inside organisms, the use of PFOS, PFOA, and other long-chain perfluorinated chemicals (PFCs) is increasingly being restricted. Because perfluorooctanesulfonamide and telomer alcohol have been identified as potentially breaking down to PFOS or PFOA, they have attracted attention as compounds that should be monitored in the environment, which involves monitoring trace concentrations.

Hardware

Durable Hardware

Reduces Maintenance Frequency and Long-term Operational Costs
In addition to ultra-high sensitivity, the GCMS-TQ8050 NX also offers high robustness. The contamination-resistant ion source and the new detector with over five times longer service life ensure that analysis can be performed reliably for a long time. With the ultra-high-sensitivity performance of the GCMS-TQ8050 NX, injection volumes can be reduced even further than before. The service life of inserts, columns, and other consumables can also be extended to reduce maintenance frequency and costs.

Highly Sensitive and Stable Ion Source
The effect of the filament’s electric potential on the ion source is reduced by placing more distance between the filament and ion source box. In addition, a shield blocks out radiant heat generated from the filament to ensure the ion source box temperature remains uniform. Since this prevents any active spots within the ion source, it provides higher sensitivity for analysis. (Patent: US7939810)

High-Performance Quadrupole Mass Filter
The high-accuracy mass filter with pre-rods and patented electric field control technology achieves high-accuracy mass separation performance.
Also, the pre-rods minimize quadrupole contamination and eliminate the need for quadrupole maintenance.

Long-Life Detector
Exhaustive efforts to reduce detector loads during analysis resulted in a significantly longer detector service life. Consequently, the instrument needs to be maintained much less frequently, which results in greater uptime.

Because the GCMS-TQ8050 NX is able to detect ultra-trace ions with high sensitivity, it can also achieve high quantitative accuracy even from trace sample quantities. Therefore, injection volumes can be reduced during analysis to reduce the analytical loads on the insert, column, ion source, and other parts, and also further reduce maintenance frequency.

Oil-Free Pump (Optional)
The rotary pump can be replaced with an oil-free pump, which requires no maintenance for three years. This auxiliary vacuum pump not only maintains an oil-free environment inside the vacuum lines, it also eliminates the tedious and time-consuming tasks of replacing and disposing of the oil.

Performance

Superior Performance

High Efficiency for a Variety of High-Sensitivity Analysis
A new turbomolecular pump with higher evacuation performance achieves a superior vacuum state in the MS unit, which also provides high sensitivity in the single GC-MS mode. With the high-efficiency collision cell (UFsweeper) installed as before, high-sensitivity detection is possible even when mass resolution is increased. The new active-time management function achieves further operating efficiencies by appropriately managing the wait times that occur during maintenance, while switching systems, or when the system is used by multiple users, to extend the operating time.

New Flow Controller Achieves Exceptional Split filter Reproducibility
A new flow controller (AFC) with a CPU uses various control methods to control carrier gas flow to a constant flow speed, flowrate, or pressure. It can also accurately trace the analytical conditions already being used. In addition, the split line filter can be replaced without any tools. Internal contamination can be confirmed visually, ensuring filters are replaced at the proper time.

Advanced GC Oven
The improved temperature control function enables more precise temperature control of the GC oven, which improves the precision of retention time reproducibility. In addition, three oven cooling rate levels can be specified to minimize damage to column liquid phases and maximize the service life.

UFsweeper™ High-Efficiency Collision Cell
Shimadzu’s proprietary UFsweeper technology efficiently sweeps residual ions out of the collision cell to achieve high CID efficiency and fast ion transport. That minimizes crosstalk and enables trace analysis.

New Large-Capacity Differential Vacuum System
A more stable vacuum system was achieved by using a new turbomolecular pump that offers higher evacuation efficiency. Consequently, because it is able to maintain a high vacuum level even during MRM analysis with a collision gas (argon) introduced, it enables highly accurate trace analysis.

Detection with High Separation by High Mass Resolution
In many cases, even using MRM analysis does not provide sufficient separation for quantitative analysis of ultra-trace compounds in biological samples or food samples that contain large amounts of impurities, for example. Using the GCMS-TQ8050 NX, compounds can be detected with high sensitivity even if high mass resolution is specified. Therefore, it can clearly detect compounds that previously could not be separated from impurities.

High-Sensitivity Analysis by Single GC-MS Mode
Due to a highly sensitive ion source and highly sensitive detector with overdrive lenses, the GCMS-TQ8050 NX is able to select and detect generated ions efficiently. That achieves high sensitivity not only for MRM measurements in the GC-MS/MS mode, but also for scan and SIM measurements in the GC/MS mode. In addition, pre-rods help prevent quadrupole contamination, so that stable sensitivity and mass spectra can be obtained even when samples containing many matrices are analyzed.

Active-Time Management™ That Accurately Determines Operation Time
Time Management during Instrument Startup/Shutdown

The mass spectrometer has to be operated in a vacuum condition, the startup and stopping of the system takes time depending on the condition. Determining this can be a challenge. Since the amount of time that the system takes when starting up or stopping is displayed in real time, it is easy to accurately determine when maintenance of the ion source or analysis is possible. Moreover, tasks that until now needed to be performed by the user, such as leak checks upon system startup and auto tuning, are now performed automatically.

Time Management during Sample Injection Port Maintenance
The Easy sTop function, used to safely maintain the sample injection port without releasing the vacuum, displays the remaining time (cooling-down time) when the septum or the insert can be replaced in real time. Maintenance time can be minimized by understanding the accurate remaining time.
Furthermore, by using a ClickTek™ nut on the top of the sample injection port, the port can be opened or closed without tools, by simply using fingers to twist a lever. That enables faster and easier insert replacement than ever before.

Time Management for Continuous Analysis
By displaying the time required for continuous analysis in real time, the time when the current continuous analysis will finish can be accurately confirmed. This increases the instrument operating time (active time) by reducing standby time required during continuous analysis or while switching between different users. In addition, because this function makes it easier to schedule the timing for analysis preparations, such as sample preparation and pretreatment, based on the finish time of the previous analysis, it enables analytical processes to be performed more efficiently, which can help improve work-life balance.

Simple Column Replacement Using the Twin Line MS System
By connecting the outlet ends of two different columns to the MS at the same, different application data can be acquired without shutting OFF the MS vacuum. Since no flow restrictors are used, there are no losses from adsorption or other factors, and methods and retention times used for analysis with one column can continue to be used unchanged. The new large-capacity differential vacuum system ensures sensitivity does not decrease even when two columns are connected. Due to the separation from impurities and separation between isomers, the system can switch between different types of columns for measurements without actually replacing columns.

Operation

Reliable Operation

Accurate Processes from Method Creation to Data Analysis
The Smart Database™ series, which are specialized for various fields, and Smart MRM™ function, which optimizes sensitivity, can be used to accurately create methods for ultra-trace analysis and reliably achieve high-sensitivity analysis from MRM measurements. LabSolutions Insight™ software, designed to support quantitative analysis of multianalyte data, enhances the throughput of data analysis from simultaneous analysis of multiple components in trace concentrations. The extensive accuracy control functions enable decisions to be made based on the easy-to-understand visualization of quantitative analysis and accuracy control results.

Automatic Method Creation

The Smart MRM technology automatically creates methods with measurement times optimized for each component based on the Smart database. The Automatic Adjustment of Retention Time (AART) function incorporated in the system estimates retention times with high accuracy. When creating methods for simultaneous multicomponent analysis, the complicated process of configuring measurement parameters made it difficult to prepare appropriate methods. By using the Smart MRM function, however, it is possible to automatically create methods in which data are acquired with high sensitivity only during the elution time of the target components. In addition to MRM methods, SIM methods can be created.

Smart Database Series Supporting Accurate Quantitative Determinations in MRM Analysis
Information about optimal transitions is preregistered in the Smart Database. That means Smart MRM can be used to create optimized methods without having to evaluate analytical conditions. The Smart Database provides powerful support for performing highly reliable analysis.

In particular, the «Smart Environmental Database» is extremely useful for analysis of environmental pollutants, which require trace analysis.

Not only are MRM information and stable isotope labeled compounds (IS) for target analysis components registered in the Smart Environmental Database, but also the optimal columns for separating each compound are set, so trace analysis can be smoothly performed without having to set the conditions for each compound.

LabSolutions Insight

LabSolutions Insight has been designed to drastically simplify the review process and transform data processing.

Products

Optional Products

HS-20 Headspace Sampler
In combination with the HS-20 headspace sampler, the GCMS-TQ8050 NX can perform quantitative analysis for impurities in pharmaceuticals. In particular for highly toxic compounds for which trace determination is required, accurate quantitative analysis can be carried out down to low concentrations with MRM analysis using the GCMS-TQ8050 NX.

AOC-6000 Multifunctional Autosampler
For target substances that require femtogram-level trace analysis, it is difficult to perform sample preparation, such as dilution and adding internal standards, due to the high toxicity. The AOC-6000 features a robotic tool changer (RTC) function that performs all steps from adding the internal standard to diluting samples automatically. Using this autosampler allows the user to perform everything from sample preparation to analysis as a continuous process, which can dramatically increase analytical throughput.

Function

Introduction to Function with the Videos

Shimadzu’s GCMS-TQ8040 NX: Everything you always wanted to know about SmartMRM, MRM Optimization, the Smart Database Series, and more.»
1. Smart MRM
This describes Smart MRM, which allows you to use the high sensitivity of MRM analysis to analyze more than 400 components in a single run.